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Mesenchymal Stem Cells (MSCs)

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Mesenchymal stem cells

Mesenchymal stem cells (MSCs) are stem cells, meaning they are cells that can differentiate and become other cells. In fact, they are the cells from which all other cells are derived. Mesenchymal stem cells are grouped between the term “multipotent” and the term “pluripotent.”

MSCs in culture are adherent, proliferating, and capable of multilineage differentiation into many tissues such as chondrocytes, osteoblasts, myocytes, and neurons.

MSCs also produce a range of secretions such as RNA, growth factors & anti-inflammatory cytokines, and extracellular vesicles/exosomes, which is unique to early passage MSCs as with further culture these secretions levels diminish.

What makes MSCs unique is that when they’re cultured outside the body, they multiply quickly but don’t differentiate into anything specific until a unique stimulus is applied. What that means is that by culturing these cells, a large number of them can be grown in a relatively short period. The Regenerative and Therapeutic potential is obvious.

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MSCs start to lose their stem cell characteristics almost undetectably from the moment in vitro culture begins. Utilizing MSC as early as possible, in therapeutic numbers will deliver the highest levels of regenerative and immune modulation potential.

When looking at the Telomere length as a marker of aging, cells with telomere shortening are expected to have reduced proliferative, differentiative and homing capacity. From our data UCMSC expansion of beyond 10 population doublings leads to an average loss of 2.5-3.5 kb of telomere sequence, this loss is significant. This telomere shortening & stem cell functionality decline amplifies with further culture exceeding 10 population doublings.

SC21 MSCs are produced with a non-enzymatic cell culture method which produces higher yields, higher viability, higher expression of mitosis and cell cycle-related genes, and a unique secretion profile of growth factors, cytokines, and extracellular vesicles (EVs)

SC21 Available MSC Sources

Umbilical Cord Mesenchymal Stem Cells:

UC-MSCs

Amniotic Membrane Mesenchymal Stem Cells:

AM-MSCs

Induced Mesenchymal Stem Cells:

i-MSCs

Adipose Tissue Mesenchymal Stem Cells:

A-MSCs

Bone Marrow Mesenchymal Stem Cells:

BM-MSCs