The Next Chapter in Cellular Medicine
Extracellular Vesicles contain biomolecules, such as RNA, proteins, lipids and carbohydrates, which play an important role in cell communication.
Recent findings have ignited huge interest on EVs by for their role in intercellular communication, pathogenesis, and as possible reservoirs of biomarkers.
SC21 lab studies the effect of extracellular vesicles on immunomodulation regeneration pathways, and uses novel methods for extracellular vesicle isolation from cell cultures and biological fluids.
EVs provide a new era of cellular-derived therapies in a cell-free-cell therapy manner.
What Are Extracellular Vesicles
Extracellular Vesicles are composed of three major classes :
- Exosomes (30 – 100 nm) originating from multi vesicular bodies (MVB).
- Microvesicles (100-500 nm) directly bud from the plasma membrane.
- Apoptotic bodies (500 nm – 5µm) are a population of extracellular vesicles secreted during cell death by apoptosis.
The biological function of EVs is to maintain cellular and tissue homeostasis by transferring critical biological cargos to distal or neighboring recipient cells.
The use of extracellular vesicles (EVs) as cell free therapy is a promising approach to stimulate tissue regeneration, immunomodulation, and neuroprotecton.
Mesenchymal Stem Cell-derived EVs
With the current breakthroughs in scientific and clinical research into Mesenchymal Stem Cell EVs opportunity has risen for the development of high impact biopharmaceuticals for delivery of therapeutic molecules to our bodies cells.
Preclinical and underway clinical studies indicate that the proteins, messenger RNA and microRNA within MSC EV’s can improve the function of aging, injured or diseased cell, tissues and organs.
As an ideal vehicle for delivery, the lipid membrane of EVs serves not only to protect proteins and RNA from degradation, but also allows EVs to reach cells in parts of the body that many drugs cannot. EVs are able to cross the blood brain barrier and also penetrate solid tissue masses.
Clinical Applications of MSC EVs
With the ever increasing understanding of cellular and biochemical processes involved in disease, injury, and regeneration pathways, MSC EVs are a front runner for therapeutic biologics that can influence cellular behavior.
Continued studies will support findings that MSC extracellular vesicles can be implemented as a novel treatment for many aging, autoimmune, inflammatory, degenerative, traumatic and malignant conditions by optimizing the functions of cells and tissues involved in pathogenesis of disease and injury.
Therapeutic Properties of MSC EVs
Investigation into the biological effects of MSC EVs with further scientific research and clinical trials should be performed to demonstrate the safety and efficacy of EV-based therapy for cardiovascular, neurologic, musculoskeletal and dermatologic conditions and more.
Current data collected from various institutes performing clinical trials with the use of MSC-EVs show a range of therapeutic actions which can greatly impact many of today’s chronic diseases and in the quest to tackle human aging. This include but not limited to: